The NBC Today show presenter's 84-year-old mother Nancy Guthrie disappeared from her Arizona home on February 1 and police have been treating her disappearance as a kidnapping.
While Guthrie previously admitted she does not think her mother is still alive, she refuses to stop looking for her.
In a post on Instagram, Guthrie shared a picture of Jesus' ascension with "Oh my, my soul it cries out, soul, it cries out", written over the top.
In a heartbreaking addition, Guthrie wrote on the bottom: "Bring her home," alongside a heart emoji.
According to reports, ransom notes were sent to local media outlets - furthering rumours that Nancy was taken against her will.
Pima County Sheriff Chris Nanos shared an update on the case on May 12, revealing no suspects had been identified, but adding that his department and the FBI were "working hard to get this resolved".
Guthrie previously said she had accepted Nancy was no longer alive after receiving a message from a higher power.
During a previous interview with her Today show colleague Hoda Kotb, Savannah cried as she explained: "Early on, I felt that I heard, one of the very few times in my life, I did hear God speak to me.
"As I said to myself: 'I can handle anything. I just can't handle not knowing ... I have to know'. And I heard a voice and it said: 'You do know where she is. She's with me.'
"So whether she's on this earth still or whether she's in heaven, I know where she is. I know who she's with. But we need to know."
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