It's curtains for Pep Guardiola and Mohamed Salah, too.
Emotions are sure to run high in the final round on Sunday of a season that has already delivered a relatively new champion - Arsenal hadn't won since 2004 before clinching it on Tuesday - but still has plenty of stories to tell when all 10 games are played concurrently.
Like which of two recent winners of European competitions - 2023 Conference League champion West Ham or 2025 Europa League champion Tottenham - will be the final team joining Wolverhampton and Burnley in getting relegated.
West Ham have it all to do to maintain their 14-year top-flight status.
They are in third-to-last place, two points behind Tottenham with an inferior goal difference of 12.
West Ham must beat Leeds at home and also need Tottenham to lose at home to Everton.
Tottenham being relegated would be a huge development. Spurs have been in the Premier League since the competition was rebranded in 1992, and last played in the second tier in the 1977-78 season.
It's not quite been the farewell that Salah might have hoped for at Liverpool.
The Egypt winger is leaving after nine years but not on the best terms with his manager, having taken an indirect swing at Arne Slot in a social media post last weekend when he said Liverpool needed to recover their identity and "go back to being the heavy metal attacking team that opponents fear".
This latest public swipe came five months after he spoke of his relationship with Slot breaking down and feeling blamed for the team's poor form.
Salah will want a big send-off in his final game, which is against Brentford at Anfield, but it remains to be see how Slot will react.
Fifth-placed Liverpool need a point to guarantee Champions League qualification. Bournemouth, who visit Nottingham Forest, are three points back in sixth place and have an inferior goal difference.
Salah has netted 257 goals in 441 games for Liverpool and is third in Liverpool's all-time scorers' list.
Meanwhile, Guardiola is sure to be an emotional wreck for his final game in charge of Manchester City.
The club's most successful manager still had a year left on his City contract but announced on Friday he is stepping aside after a 10-year stint that has reaped 20 trophies, including six Premier League titles.
The highlight was the 2022-23 season, when City picked up the Premier League, FA Cup and Champions League treble.
The Spaniard will take charge of his final game on Sunday against Aston Villa.
Also saying goodbye at the Etihad will be Bernardo Silva and John Stones, two cornerstones and emblems of the trophy-laden Guardiola era who have confirmed their City exits.
These are also the final Premier League games in charge for Andoni Iraola at Bournemouth and Oliver Glasner at Crystal Palace, who host newly crowned champions Arsenal.
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