Ryan, who lost his place as national No.1 to Patrick Beach at the World Cup, made seven saves as hosts Osasuna pounded his goal in Pamplona.
They were, however, unable to beat the veteran who made key saves at either end of the first half.
After 70 seconds he scooped a Jorge Herrando header over the bar, and in the 44th minute palmed away a curling shot from Jon Moncayola.
Ryan was beaten near the hour mark, but only after coming sharply off his line to force Ante Budimir so wide that the striker hit the post. Aissa Mandi then scrambled it clear.
Levante, who lost their first game of the league season 3-0 at Espanyol last weekend, moved up to 16th ahead of their opening home game against Real Betis this weekend.
In Germany, Paul Okon-Engstler made his debut for Cologne in the German Cup following his post-World Cup move from Sydney FC.
The 21-year-old came on as a late substitute in the Bundesliga side's 2-1 comeback win over Wurzburger Kickers.
Cologne fell behind when David Abrangao gave third-tier Kickers the lead in the 18th minute.
But Isak Bergmann Johannesson struck in the 62nd and 77th minutes, preventing Cologne from becoming the first Bundesliga team to exit the competition.
Wolfsburg, who were relegated to the second division last season, needed late equalisers in both regular time and extra-time before beating fourth division VSG Altglienicke 6-5 on penalties. The Wolves levelled in the 83rd and 117th minutes.
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