"Unfortunately, there is no adequate, strong reaction from the world to everything that is happening," Zelenskiy said in his daily video address, noting the increasing scale and audacity of the attacks.
"This is exactly why (Russian President Vladimir) Putin does it: he simply laughs at the West, at its silence and the absence of decisive countermeasures."
Zelenskiy stated that Russia has so far rejected all proposals to end the war or at least halt the attacks.
"Russia is openly trying to destroy our civilian infrastructure, and right now, before winter, it is targeting gas infrastructure, power generation and transmission," he said.
The Russian military attacked Ukraine overnight with 53 missiles and several waves of drones.
Five people were killed and 18 others were injured across the country, Ukrainian authorities said.
Four people, including a 15-year-old, died in a combined drone and missile strike on Lviv, according to regional officials and Ukraine's emergency service.
It was the largest aerial assault on the city and surrounding region since Russia's full-scale invasion on February 24, 2022, according to Maksym Kozytskyi, head of the local military administration.
Earlier in the war, the western city of Lviv was seen as a haven from the fighting and destruction farther east.
In a Telegram post, Kozytskyi said Russia launched about 140 Shahed drones and 23 ballistic missiles across the region.
At least six more people were injured, according to a statement by Ukraine's police force.
The strike left two districts of Lviv without power and disrupted public transportation for a few hours early on Sunday, Mayor Andriy Sadovyi reported.
He added that a business complex on Lviv's outskirts caught fire following the strike, describing it as a civilian facility unlinked to Ukraine's war effort.
Zelenskiy on Sunday also lamented that the Russian attack drones contained components "that are still being supplied from Western countries and various neighbouring countries of Russia".
He expressed astonishment that, even after more than three and a half years of war, it remains unclear how to halt the supply of these critical parts.
"The nearly 500 drones that the Russians used overnight contain more than 100,000 components manufactured abroad," Zelenskiy said as an example.
with AP
