In Khost's Spera district, a southeastern border region adjacent to Pakistan's North Waziristan, three children were killed and several others wounded when drones hit the home of Haji Naeem Khan, according to the province's media chief.
In Nangarhar's Shinwar district, near Afghanistan's eastern border with Pakistan, a spokesman said four sons and two wives of a man named Shahsawar were among those injured when his house was destroyed.
Pakistan's foreign ministry and Pakistan's military media wing did not immediately respond to a Reuters request for comment.
Relations between Pakistan and Afghanistan have been strained in recent years, with officials in Islamabad accusing militants sheltering across the border of staging attacks inside Pakistan while Afghan authorities deny giving safe haven.
The strikes in Nangarhar and Khost provinces came barely a week after Pakistan's Foreign Minister Ishaq Dar joined his Chinese and Afghan counterparts in Kabul for a trilateral dialogue at which the three countries pledged to step up counter-terrorism co-operation, expand trade and extend the China-Pakistan Economic Corridor to Afghanistan.
The Taliban foreign ministry said in a statement that it "strongly condemns the violation of Afghanistan's airspace and the bombing of civilians … such irresponsible actions will inevitably have consequences".
It said Pakistan's ambassador, Ubaid-ur-Rehman Nizamani, was handed a protest note during the meeting in Kabul.
Nizamani survived an attack on Pakistan's embassy compound in Kabul in 2022 but has remained his country's top envoy despite repeated strains in ties.
