A limited number of coaches will run from the first service until about 5pm.
Significant delays of two hours or more are expected, including extended wait and travel times.
A limited number of coaches will run from first to last service between Shepparton, Seymour and Southern Cross.
Coaches will not stop at Craigieburn, Broadmeadows, Essendon or North Melbourne.
Meanwhile, the Albury line will have a limited number of coaches running until 5pm between Albury and Southern Cross, not stopping at Broadmeadows.
The Albury line will restore train schedules at 5.27pm from Albury to Southern Cross, and 6.02pm from Southern Cross to Albury.
Meanwhile, train services will not return on the Seymour, Shepparton, Swan Hill, Echuca and Maryborough lines due to trains being out of position.
V/Line asks people to travel only if they need to, helping ensure the limited services that will run are free for essential journeys.
Passengers with accessibility needs are encouraged to call 1800 800 007 before travelling for assistance.
Information about service changes, including temporary timetables, will be published on the V/Line website, the V/Line mobile app and social media, and information will be displayed at stations.