Hottle was one of two passengers in the car when it went off the road and hit a culvert in Ijamsville.
The driver was taken to a local hospital with non-life-threatening injuries, and the other passenger declined medical treatment, according to the sheriff's office.
Excessive speed is believed to be a factor in the crash, which is under investigation.
Hottle was a native signer of American Sign Language, and her family members are also deaf. Her parents, Joshua and Ketsi Hottle, shared emotional video statements about her death on social media sites.
"Kaylee's mum and four siblings are crushed," her father said in a post. "They are together at home, grieving. I am on my way to Maryland to bring Kaylee's body back home."
Hottle's heart stopped before she arrived at a hospital, transported by air from the scene of the accident, her father said.
"Very grateful for the 18 years we had together - and wish we had more," he said.
Joshua Hottle also contacted the driver, described by the sheriff's office as a 19-year-old Frederick man.
"I have forgiven you," he said. "Don't let this incident ruin the rest of your life."
In Godzilla vs. Kong and the sequel, Godzilla x Kong: The New Empire, Hottle played an orphaned girl named Jia who sees beyond Kong's threatening appearance and forms a special bond with the monster, communicating with him using sign language.
"I'm so devastated to hear this. You will be deeply missed Kaylee," her Godzilla co-star Millie Bobby Brown posted on Instagram.
Hottle previously appeared in a 2021 television episode of Magnum P.I. She was listed as appearing in the upcoming film What Doesn't Kill Us.
Other prominent deaf actors also shared messages of grief online.
"I am absolutely gutted about the passing of sweet Kaylee Hottle. May her beauty and talent be a memory for eternity," Oscar winner Marlee Matlin wrote on Instagram.
Fellow Oscar winner Troy Kotsur, who starred in the film Coda, said Hottle's death made him think of his own daughter, and reminded him not to take time for granted.
"I have no words to express on what happened this morning," Kotsur wrote, offering his "deepest condolences" to the Hottle family.
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